Description
Frizzled-10 (FZD10) is also known as FzE7 or CD350, which belongs to the G-protein coupled receptor Fz/Smo family.
Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.
FZD10 contains one FZ (frizzled) domain.
FZD10 protein is a cell surface receptor, which is activated by Wnt proteins and involved in the regulation of cellular function.
FZD10 interacts with WNT7B and MYOC